Criteria for evaluation of therapeutic efficacy
Grade 0: Ineffective
There is no discernible therapeutic effect on cancer tissue or cells.
Grade 1: Slightly effective
Apparently “viable” cancer cells (including cells having eosinophilic cytoplasm with vacuolation and swollen nuclei) account for 1/3 or more of tumor tissue, but there is some evidence of degeneration of cancer tissue or cells.
Grade 1a: viable cancer cells accounting for 2/3 or more of tumor tissue
Grade 1b: viable cancer cells accounting for 1/3 or more, but less than 2/3, of tumor tissue
Grade 1b: viable cancer cells accounting for 1/3 or more, but less than 2/3, of tumor tissue
Grade 2: Moderately effective
“Viable” cancer cells account for less than 1/3 of tumor tissue, while other cancer cells are severely degenerate or necrotic.
Grade 3: Markedly effective
There are no viable cancer cells evident.
대장암에서 수술전 항암화학요법을 받았을 경우 이에대한 치료 반응 정도를 평가하는 등급은 AJCC 에서도 언급이 되어 있을만큼 일반적으로 받아들여지는 기준이 있다. 하지만, 식도에서는 널리 받아들여지는 기준은 아직 없는 것 같고, 작년 12월에 관련 논문을 찾은 적이 있다.
Reference: Guidelines for clinical and pathologic studies on carcinoma of the esophagus, ninth edition: part II. Esophagus 2004; 1(3): 107-125. (PubMed 에서 검색이 안됨)
