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Category: 03_Study

  • Assessment of Resistance Mechanisms and Clinical Implications in Patients With EGFR T790M–Positive Lung Cancer and Acquired Resistance to Osimertinib1

    EGFR T790M 환자에서 이 내성 유전자에도 사용할 수 있는 약제를 사용할 경우 나타날 수 있는 유전자 변화에 대한 것이 나에게는 유용한 정보임. 현재 병원에서는  PANAGENE 제품을 이용하고 있는데 이 제품을 이용한 검사에서는 C797S 는 검출할 수가 없음.

    1.
    Oxnard G, Hu Y, Mileham K, et al. Assessment of Resistance Mechanisms and Clinical Implications in Patients With EGFR T790M-Positive Lung Cancer and Acquired Resistance to Osimertinib. JAMA Oncol. 2018;4(11):1527-1534. [PubMed]

  • Heterogeneity of Fibrosis in Liver Biopsies of Patients With Heart Failure Undergoing Heart Transplant Evaluation1

    간경화에서 아주 후기가 아니면 섬유화 정도가 차이가 나는 것 같다고 생각했는데, 비슷한 논문이 나왔음.

    1.
    Dhall D, Kim S, Mc P, et al. Heterogeneity of Fibrosis in Liver Biopsies of Patients With Heart Failure Undergoing Heart Transplant Evaluation. Am J Surg Pathol. 2018;42(12):1617-1624. [PubMed]

  • A model for RAS mutation patterns in cancers: finding the sweet spot 1

    RAS와 관련된 뭔가 어려운 이야기.

    1.
    Li S, Balmain A, Counter C. A model for RAS mutation patterns in cancers: finding the sweet spot. Nat Rev Cancer. November 2018. [PubMed]

  • mTOR signalling and cellular metabolism are mutual determinants in cancer1

    예전에 관심을 가졌던 mTOR pathway.

    1.
    Mossmann D, Park S, Hall M. mTOR signalling and cellular metabolism are mutual determinants in cancer. Nat Rev Cancer. November 2018. [PubMed]