single-cell RNA-seq을 통하여 H3K27M gliomas의 세포들을 따로따로 특성을 구별하여 본 논문. 막대한 비용이 들겠지만, 괜찮은 연구 접근 방법이라고 생각된다.1
병원 진단 포맷에 hyperproliferative IM이라는 항목이 있길래 공부하기 위하여 찾아봄.
Padova classification은 다음과 같음.1
TABLE 1. Gastric dysplasia and related lesions: the Padova classification
1. Negative for dysplasia
1.0 Normal
1.1 Reactive foveolar hyperplasia
1.2 Intestinal metaplasia (IM)
1.2.1 IM Complete type
1.2.2 IM Incomplete type
2. Indefinite for dysplasia
2.1 Foveolar hyperproliferation
2.2 Hyperproliferative IM
3. Non-invasive neoplasia (flat or elevated [synonym adenoma])
3.1 Low-grade
3.2 High-grade
3.2.1 Including suspicious for carcinoma without invasion
(intraglandular)
3.2.2 Including carcinoma without invasion
(intraglandular)
4. Suspicious for invasive carcinoma
5. Invasive adenocarcinoma
본문 중에서 관련된 설명
In such cases “atypical,” tortuous glandular structures are lined by mucus-depleted epithelial cells with large, hyperchromatic nuclei with thickened nuclear membrane and prominent nucleoli. Mitosis may be prominent. A similar situation arises in patients with intestinal metaplasia, usually with incomplete components in which the deep metaplastic glands are closely packed and lined by large irregular cells with large, hyperchromatic nuclei with frequent mitoses. Some glands show elongated and pseudostratified nuclei. Such lesions have been called “hyperplastic” or “hyperproliferative” or “deep” metaplasia.
1.Rugge M, Correa P, Dixon M, et al. Gastric dysplasia: the Padova international classification. Am J Surg Pathol. 2000;24(2):167-176. [PubMed]
위암과 관련된 괜찮은 논문을 하나 봐서 기록에 남김.1
신장 종양의 분류를 위한 IHC 에 대한 논문 모음들.1–4
