WeLoveDoctor

Category: 03_Study

  • Pulmonary adenofibroma

    그 동안 찾은 관련 논문들 중에서 가장 괜찮은 것이라고 생각해서 여기에 기록으로 남겨둠.1 STAT6와 ER이 IHC로 확인이 가능함.

    1.
    Fusco N, Guerini-Rocco E, Augello C, et al. Recurrent NAB2-STAT6 gene fusions and oestrogen receptor-α expression in pulmonary adenofibromas. Histopathology. 2017;70(6):906-917. [PubMed]

  • Tumor immune microenvironment (TIME)

    TIME에 대한 최근 괜찮은 것 같은 review 논문.1

    1.
    Binnewies M, Roberts E, Kersten K, et al. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nat Med. April 2018. [PubMed]

  • 3D modelling

    논문들을 보면서 다음번에는 나도 한 번쯤 넣어보고 싶다고 생각한 figure들이 있다. protein modelling도 그 중의 하나이다.1 다음번을 위하여 참고 method가 있는 논문 하나를 추가한다.

    1.
    Robichaux J, Elamin Y, Tan Z, et al. Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer. Nat Med. April 2018. [PubMed]

  • Classification of pituitary adenoma

    Table 1 Clinicopathological classification of pituitary endocrine tumours

    The classification is based on the three following characteristics:

    1: tumour diameter into micro (<10 mm), macro (≥10 mm) and giant (>40 mm) by MRI

    2: tumour type into GH, PRL, ACTH, FSH/LH and TSH by immunocytochemistry

    3: tumour grade based on the following criteria:

     Invasion defined as histological and/or radiological (MRI) signs of cavernous or sphenoid sinus invasion

     Proliferation considered on the presence of at least two of the three criteria:

      Ki-67: >1 % (Bouin-Hollande fixative) or ≥3 % (formalin fixative)

      Mitoses: n >2/10 HPF

      P53: positive (>10 strongly positive nuclei/10 HPF)

    The five grades are the following:

     Grade 1a: non-invasive tumour

     Grade 1b: non-invasive and proliferative tumour

     Grade 2a: invasive tumour

     Grade 2b: invasive and proliferative tumour

     Grade 3: metastatic tumour (cerebrospinal or systemic metastases)1
    1.
    Trouillas J, Roy P, Sturm N, et al. A new prognostic clinicopathological classification of pituitary adenomas: a multicentric case-control study of 410 patients with 8 years post-operative follow-up. Acta Neuropathol. 2013;126(1):123-135. [PubMed]