Histopathologic Features of Colitis Due to Immunotherapy With Anti-PD-1 Antibodies

Immune check point drug 가 널리 사용되고 있다. 그리고 그에 따른 부작용(adverse drug reaction)이 있으며, 그 중에 하나라고 할 수 있는 장염의 조직학적 소견에 관한 논문을 찾았다. 초록에서 필요한 부분을 발췌하였음.[1]

• The most common pattern of injury observed (5/8 cases) was an active
  colitis with neutrophilic crypt microabscesses and with prominent
  crypt epithelial cell apoptosis and crypt atrophy/dropout.
• The remainder of cases (3/8) showed a lymphocytic colitis-like pattern, characterized by increased intraepithelial lymphocytes and surface epithelial injury. Apoptosis was also often increased in these cases but crypt atrophy/dropout was not present.
• In patients who experienced recurrence of anti-PD-1 colitis, histologic features were similar to the initial insult but, in addition, features of chronicity developed that mimicked inflammatory bowel disease (basal
  lymphoplasmacytosis and crypt architectural irregularity, and
  Paneth cell metaplasia in 1 case).