cIMPACT-NOW update 3: recommended diagnostic criteria for “Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV”.1
Integrated diagnosis: Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma,
WHO grade IV.
Histological diagnosis Anaplastic astrocytoma
Molecular information
IDH: wildtype (IDH1 and IDH2, sequencing)
EGFR: High-level amplification (FISH)
Chromosome 7/10 status: whole chromosome 7 gain/whole chromosome 10 loss (FISH)
TERT promoter: mutated (sequencing)
Integrated histologic and molecular grade WHO grade IV
이렇게 진단할려면 어느 정도의 규모의 병리 센터에서 할 수 있을것인가..
1.
Brat D, Aldape K, Colman H, et al. cIMPACT-NOW update 3: recommended diagnostic criteria for “Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV”. Acta Neuropathol. September 2018. [PubMed]