Tag: fuhrman

  • Furhman grade

    Fuhrman grade 에 정말로 현미경 배율이 언급되는지 찾아봤더니 정말로 있었다. OTL

    Grade 1 tumors were composed of cells with small (approximately 10um) round uniform nuclei with inconspicuous or absent nucleoli.

    Grade 2 tumors had larger (approximately 15um) nucleti which exhibited irregularities in outline and nucleoli when examined under high (400x) power.

    Grade 3 tumors had even larger nuclei (approximately 20um) with an obvisously irregular outline and prominent large nucleoli even at low (100x) power.

    Grade 4 tumors exhibit features similar to the grade 3 tumors with the addition of bizarre, often multilobed nuclei and heavy chromatin clumps. These tumors often had areas of spindled-shaped cells resembling sarcomas.

    Each tumor was graded by the most malignant or highest grade exhibited even if only focal.
    Multiple grades coexisted in 15% of tumors.

    Reference: Fuhrman SA, Lasky LC, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. The American journal of surgical pathology 1982;6:655-63.

  • Fuhrman Grading System

    Fuhrman Grading System
    . Grade X (GX): Cannot be assessed
    . Grade 1 (G1): Nuclei round, uniform, approximately 10 um in diameter; nucleoli inconspicuous or absent
    . Grade 2 (G2): Nuclei slightly irregular, approximately 15 um in diameter; nucleoli evident
    . Grade 3 (G3): Nuclei very irregular, approximately 20 um in diameter; nucleoli large and prominent
    . Grade 4 (G4): Nuclei bizarre and multilobated, 20 um or greater in diameter, nucleoli prominent, chromatin
    clumped

      막상 책에서 찾으려고 하면 잘 나오지 않는 것 중의 하나…

    Reference:
    1. Srigley JR, Amin MB, Delahunt B, et al. Protocol for the examination of specimens from patients with invasive carcinoma of renal tubular origin. Arch Pathol Lab Med 2010; 134: e25-30.