TABLE 6.50 Histologic Lesions of Graft Versus Host Disease
Grade Histology
1 Mild necrosis of individual crypts
2 Crypt abscesses and crypt cell flattening
3 Dropout of many crypts
4 Flat mucosa
3 Dropout of many crypts
4 Flat mucosa
TABLE 6.51 Situations Associated with Increased Apoptosis
Graft vs. host disease
Rejection
Chemotherapy
Radiation therapy
Zinc deficiency
Fasting
Inflammatory bowel disease
AIDS enteropathy
Thymoma
Certain drugs
Viral infections
Cell-mediated immune reactions
Autoimmune enterocolitis
Reference: Fenoglio-Preiser CM, Noffsinger AE, Stemmermann GN, Lantz PE, Isaacson PG. Gastrointestinal Pathology: An Atlas and Text 3rd edition ed: Lippincott Williams & Wilkins; 2007.