Category: Study

이 논문에서는 다음의 5가지로 분류하고 있음.¹

The type I pattern is characterized by multicentric Castleman disease–like morphology.
The type II pattern is reactive follicular hyperplasia-like with occasional eosinophils in the interfollicular regions.
The type III pattern is characterized by interfollicular plasmacytosis and immunoblasts, with preserved nodal architecture, paracortical hyperplasia, small vessel proliferation, and a polymorphous infiltrate rich in IgG4-positive plasma cells.
The type IV pattern shows PTGC-like morphology characterized by large nodules of lymphocytes and IgG4-positive plasma cells distributed in the germinal centers of the nodules.
The type V pattern shows inflammatory pseudotumor-like morphology, similar to that of extranodal lesions.

single-cell RNA-seq을 통하여 H3K27M gliomas의 세포들을 따로따로 특성을 구별하여 본 논문. 막대한 비용이 들겠지만, 괜찮은 연구 접근 방법이라고 생각된다.¹

병원 진단 포맷에 hyperproliferative IM이라는 항목이 있길래 공부하기 위하여 찾아봄.

Padova classification은 다음과 같음.¹
TABLE 1. Gastric dysplasia and related lesions: the Padova classification
1. Negative for dysplasia
1.0 Normal
1.1 Reactive foveolar hyperplasia
1.2 Intestinal metaplasia (IM)
1.2.1 IM Complete type
1.2.2 IM Incomplete type
2. Indefinite for dysplasia
2.1 Foveolar hyperproliferation
2.2 Hyperproliferative IM
3. Non-invasive neoplasia (flat or elevated [synonym adenoma])
3.1 Low-grade
3.2 High-grade
3.2.1 Including suspicious for carcinoma without invasion
(intraglandular)
3.2.2 Including carcinoma without invasion
(intraglandular)
4. Suspicious for invasive carcinoma
5. Invasive adenocarcinoma

본문 중에서 관련된 설명
In such cases “atypical,” tortuous glandular structures are lined by mucus-depleted epithelial cells with large, hyperchromatic nuclei with thickened nuclear membrane and prominent nucleoli. Mitosis may be prominent. A similar situation arises in patients with intestinal metaplasia, usually with incomplete components in which the deep metaplastic glands are closely packed and lined by large irregular cells with large,  hyperchromatic nuclei with frequent mitoses. Some glands show elongated and pseudostratified nuclei. Such lesions have been called “hyperplastic” or “hyperproliferative” or “deep” metaplasia.

1.

Rugge M, Correa P, Dixon M, et al. Gastric dysplasia: the Padova international classification. Am J Surg Pathol. 2000;24(2):167-176. [PubMed]

위암과 관련된 괜찮은 논문을 하나 봐서 기록에 남김.¹

• 여러 병원의 자료를 이용하여 위암의 분자학적 분류가 가능한 방법을 제시하였음.
• Cox 같은 다변량 분석 자료가 없는데.. 그럼에도 불구하고 괜찮은 결과를 이끌어 낸 것 같음. 하지만 Stage 등과 다변량 분석 결과가 없다는 점에서는 compounding factors에 대한 고려가 부족하거나 해봤을 때 의미가 없었을 가능성이 높음.
• 개인적으로는 MP type의 전형적인 histology 같은 것이 더 궁금함. 
  1.

  Oh S, Sohn B, Cheong J, et al. Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype. Nat Commun. 2018;9(1):1777. [PubMed]