환자군이 조금 까다롭다. Resectable gastric cancer 환자에 대하여 굳이 preoperative chemo를 할 필요가 있을지 모르겠다.1
Gleason grade를 자꾸 까먹어서 기록해둠.1
이 논문에서는 다음의 5가지로 분류하고 있음.1
The type I pattern is characterized by multicentric Castleman disease–like morphology.
The type II pattern is reactive follicular hyperplasia-like with occasional eosinophils in the interfollicular regions.
The type III pattern is characterized by interfollicular plasmacytosis and immunoblasts, with preserved nodal architecture, paracortical hyperplasia, small vessel proliferation, and a polymorphous infiltrate rich in IgG4-positive plasma cells.
The type IV pattern shows PTGC-like morphology characterized by large nodules of lymphocytes and IgG4-positive plasma cells distributed in the germinal centers of the nodules.
The type V pattern shows inflammatory pseudotumor-like morphology, similar to that of extranodal lesions.
single-cell RNA-seq을 통하여 H3K27M gliomas의 세포들을 따로따로 특성을 구별하여 본 논문. 막대한 비용이 들겠지만, 괜찮은 연구 접근 방법이라고 생각된다.1