A Newly Recognized Histologic Pattern of IgG4-related Lymphadenopathy: Expanding the Morphologic Spectrum

이 논문에서는 다음의 5가지로 분류하고 있음.1

The type I pattern is characterized by multicentric Castleman disease–like morphology.
The type II pattern is reactive follicular hyperplasia-like with occasional eosinophils in the interfollicular regions.
The type III pattern is characterized by interfollicular plasmacytosis and immunoblasts, with preserved nodal architecture, paracortical hyperplasia, small vessel proliferation, and a polymorphous infiltrate rich in IgG4-positive plasma cells.
The type IV pattern shows PTGC-like morphology characterized by large nodules of lymphocytes and IgG4-positive plasma cells distributed in the germinal centers of the nodules.
The type V pattern shows inflammatory pseudotumor-like morphology, similar to that of extranodal lesions.

1.
Chen Y, Chen Y, Wang M, Medeiros L, Chang K. A Newly Recognized Histologic Pattern of IgG4-related Lymphadenopathy: Expanding the Morphologic Spectrum. Am J Surg Pathol. 2018;42(7):977-982. [PubMed]